R É S U M É

R É S U M É

Doc. MVDr. Tomáš Sládek, CSc.

Vice President and Chief Scientific Officer of MEDEA PHARM s.r.o.

EDUCATION

*Doc.* Habilitation 3/17/1994	Academic degree corresponding to Associate Professor of Physiology and Pathophysiology Medical Faculty Masaryk University 662 43 Brno
*CSc.* *(corresp. to Ph.D.)* diploma 3/15/1985	Postgraduate course of supervised research (12/79 - 3/85) University of Veterinary Medicine Palackého Str. 1/3 Brno
MVDr. (corresp. to M.V.D.) diploma 3/25/1972	University level (10/66 - 3/72) University of Veterinary Medicine Palackého street 1/3 Brno

WORK EXPERIENCE

Vice President and Chief Scientific Officer of MEDEA PHARM s.r.o. 07/1999 – present	Srbská 46 612 00 Brno
*Programme Manager, Department of Technical Strategy* 05/1998 – 02/1999	Headquarters LACHEMA, a.s. Karásek 1 Brno
*Head of Department of Clinical Pharmacology* 10/1995 - 04/1998	Headquarters LACHEMA, a.s. Karásek 1 Brno
Associate Professor 3/1994 - 10/1995	Inst. Pathol. Physiol. Medical Faculty Masaryk University 662 43 Brno
*Visiting Scientist* award from East Eur. Exchange Program of MRC of Canada 1/93 - 12/93	Dept. Physiol. Medical Faculty University of Ottawa 451 Smyth Road Ottawa, K1H 8M5 Ont. Canada
*Senior Lecturer* 10/1990 - 3/1994	Inst. Pathol. Physiol. Medical Faculty Masaryk University 662 43 Brno
Part-time Expert 10/1990 - 12/1991	Research Institute of Fine Chemicals LACHEMA n.e. Karásek 1 621 33 Brno
*Head of Department of Pharmacology and Toxicology* 10/1985 - 9/1990	Research Institute of Fine Chemicals LACHEMA n.e. Karásek 1 621 33 Brno
Operating Room Manager 1/1975 – 12/1979	Artificial Heart Research Center of the Regional Institute of Health affiliated to the Medical Faculty of Masaryk University in Brno
Research Fellow (experimental surgery 8/1972 - 9/1985	Artificial Heart Research Center of the Regional Institute of Health affiliated to the Medical Faculty of Masaryk University in Brno

MEMBERSHIP IN ACADEMIC BODIES AT MASARYK UNIVERSITY

Doctoral Committee of Physiology and Pathological Physiology

PUBLICATIONS

Full Length Papers:	79
Patents:	2
Number of Citations:	148

LIST OF THE MOST IMPORTANT PUBLICATIONS

1.	Sladek T, Sladkova J, Kolar F, Papousek F, Cicutti N, Korecky B, Rakusan K. The effect of AT₁ receptor antagonist on chronic cardiac response to coronary artery ligation in rats. Cardiovasc Res 1996;31:568–576. [№. of citations: 47] Abstract Free Full Text
2.	Sladek T, Gerova M, Znojil V, Devat L. Morphometric characteristics of cardiac hypertrophy induced by long-term inhibition of NO synthase. Physiol Res 1996;45(4):335 –338. [№. of citations: 33] Abstract
3.	Rakusan K, Cicutti N, Sladek T. Ischemic heart: microcirculatory aspects. Adv Exp Med Biol 1996;388:457–461.
4.	Filkuka J, Sladek T, Kleinwächter V, Neuhybel P, Hofirek B, Kiss F. Study of chronic toxicity of calcium antagonist diltiazem (BLOCALCIN 60 Lachema): Histopathological study on Beagle dogs. Scripta med. 1990;63:463–470.
5.	Juraskova V, Sladek T. Antimetastatic activity of diltiazem on LS/BL tumor cells in liver-tumor-colony assay. Neoplasma 1990;37:343–347. [№. of citations: 4] Abstract
6.	Dostal M, Vasku J, Dolezel S, Pavlicek V, Necas J, Sladek T. [The effect of reperfusion and diltiazem on the extent of experimental infarct in the dog]. Cesk. Fysiol. 1989;38(6):561–564.
7.	Kostal M, Rajcani J, Sladek T. [Treatment of mice infected with herpes simplex viruses using acycloguanosine]. Bratisl Lek Listy 1988;89(7):495–503.
8.	Salamoun J, Sprta V, Sladek T, Smrz M. Determination of acyclovir in plasma by column liquid chromatography with fluorescence detection. J Cromatogr Biomed Appl 1987,420:197–202. [№. of citations: 25]
9.	Dolezel S, Gerova M, Hartmannova B, Sladek T, Dostal M, WENDSCHE P, JANECKOVA H, Vasku J. Adrenerge Innervation des Hundeherzens nach einseitiger Sympathektomie, Verh Anat Ges 1986;80:555–557.
10.	Dolezel S, Vasku J, Hartmannova B, Filkuka J, Cerny J, Dostal M, Sladek T, Urbanek E. Innervation of atrial stumps in calves living with the TNS-Brno II artificial heart. Artif. Organs 1985;9(1):53–58. Abstract
11.	Sladek T, Filkuka J, Dolezel S, Vasku J, Hartmannova B, Travnickova J. The border zone of the early myocardial infarction in dogs: its characteristics and viability. Basic Res Cardiol 1984;79:344–349. [№. of citations: 6] Abstract
12.	Trbusek V, Fiala V, Vrbova M, Urbanek P, Vasku J, Urbanek E, Pavlicek V, Sotolova O, Dostal M, Sladek T. The heart prosthesis – biocompatibility with living tissue [letter]. Int J Artif Organs 1984;7:163–164.
13.	Hartmannova B, Vasku J, Dolezel S, Urbanek E, Filkuka J, Sladek T, Krcek L, Guba P, Dostal M, Cerny J. Mechanisms causing the death of 8 calves surviving with implanted artificial heart from 31 to 173 days. Exp Pathol 1984;26:221–225. Abstract
14.	Vasku J, Cerny J, Urbanek E, Dostal M, Urbanek P, Guba P, Pavlicek V, Sladek T Smutny M. A comparative study of a group of eight calves, surviving longer than 1 month with the total artificial heart. Artif Organs 1983;7(4): 470–478. [№. of citations: 3] Abstract
15.	Dostal M, Vasku J, Cerny J, Guba P, Pavlicek V, Sladek T, Janeckova H, Sotolova O, Urbanek E. Some problems associated with the implantation of a cardiac prosthesis and with early postoperative care in animals with a total artificial heart. Life Support. Syst 1983;1:281–290. Abstract
16.	Dolezel S, Sladek T, Vasku J. [Histochemical aspects of experimental myocardial infarct in relation to sympathetic innervation]. Cesk Fysiol 1982;31(6):571–576.
17.	Vasku J, Cerny J, Hanzelka P, Urbanek E, Dostal M, Urbanek P, Guba P, Pavlicek V, Krcek L, Sladek T, Hartmannova B, Filkuka J, Janeckova H, Sotolova O, Sotakova E, Dolezel S, Krcma V, Cidl K, Bednarik B. 150-day survival of a calf with a polymethylmethacrylate total artificial heart: TNS-BRNO-II. Artif Organs 1981;5(4):388–400. [№. of citations: 1]
18.	Cerny J, Vasku J, Dostal M, Gregor Z, Hanzelka P, Wendsche P, Sladek T, Guba P, Pavlicek V, Sotolova O, Urbanek E, Urbanek P, Krcek L, Janeckova H, Sotakova E, Hartmannova B, Dolezel S. [Surgical aspects of artificial heart implantation]. Rozhl Chir 1981;60:354–360.
19.	Sladek T, Vasku J, Urbanek E, Filkuka J, Dolezel S, Wendsche P, Hartmannova B, Sotolova O. Reperfusion of coronary arteries after temporary occlusion in dogs. J Cardiovasc Surg (Torino) 1980;21(6):695–702. Abstract
20.	Dolezel S, Gerova M, Gero J, Sladek T, Vasku J. Monoaminergic pathways to the coronary arteries and to the myocardium. Acta Anat (Basel) 1980;108:490–7. [№. of cit.: 3] Abstract
21.	Vasku J, Cerny J, Hanzelka P, Vasku Jan, Urbanek E, Dostal M, Urbanek P, Guba P, Pavlicek V, Krcek L, Sladek T, Hartmannova B, Filkuka J, Janeckova H, Sotolova O, Sotakova E, Dolezel S, Krcma V, Cidl K, Bednarik B. The 150-day survival of a calf with the polymetyl matacrylate total artificial heart – TNS BRNO – II. Artificial Organs 1980;5:388–400.
22.	Dolezel S, Gerova M, Gero J, Sladek T, Vasku J. Adrenergic innervation of the coronary arteries and the myocardium. Acta Anat 1978;100:306–316. [№. of cit.: 26] Abstract
23.	Sladek T, Filkuka J, Pejchlova M, Sotolova O, Hartmannova B, Vitek J, Dostal M, Stepanek V, Urbanek E, Vasku J, Bednarik B. Suppression of the progress of necrosis after coronary artery ligation in the dog by pharmacologic interventions. J Cardiovasc Surg (Milano) 1976;17:321–328. Abstract